Heather Francis Selected Research

Enzymes

1/2023	Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity.
1/2023	Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation.
1/2022	Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.
10/2017	Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation.
11/2014	Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
5/2012	Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.

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Heather Francis Research Topics

Disease

35	Fibrosis (Cirrhosis) 01/2023 - 08/2006
32	Liver Cirrhosis (Hepatic Cirrhosis) 12/2023 - 09/2012
31	Inflammation (Inflammations) 11/2023 - 10/2004
30	Cholestasis 10/2023 - 05/2002
28	Cholangiocarcinoma 04/2021 - 06/2002
26	Neoplasms (Cancer) 01/2022 - 12/2005
20	Liver Diseases (Liver Disease) 11/2023 - 10/2004
16	Hyperplasia 01/2022 - 05/2007
14	Non-alcoholic Fatty Liver Disease 01/2023 - 01/2018
12	Sclerosing Cholangitis 01/2023 - 06/2004
7	Alcoholic Liver Diseases (Alcoholic Liver Disease) 01/2021 - 09/2012
6	Fatty Liver 10/2021 - 02/2014
5	Hepatocellular Carcinoma (Hepatoma) 01/2023 - 08/2008
5	Carcinogenesis 01/2021 - 08/2008
4	Obesity 01/2023 - 01/2018
4	Body Weight (Weight, Body) 01/2019 - 08/2009
4	Necrosis 10/2014 - 10/2004
3	Cystic Fibrosis (Mucoviscidosis) 01/2023 - 04/2010
3	Liver Neoplasms (Liver Cancer) 01/2021 - 12/2011
3	Insulin Resistance 01/2021 - 01/2019
2	Cholangitis 01/2023 - 01/2023
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2023 - 01/2019
2	Alcoholic Fatty Liver 01/2022 - 01/2020
2	Neoplasm Metastasis (Metastasis) 07/2021 - 11/2011
2	Disease Progression 11/2020 - 01/2018
2	Wounds and Injuries (Trauma) 04/2020 - 01/2018

Drug/Important Bio-Agent (IBA)

20	Histamine (Histamine Dihydrochloride)FDA Link 01/2023 - 06/2010
16	Bile Acids and Salts (Bile Acids)IBA 11/2023 - 05/2002
15	Secretin FDA Link 01/2023 - 04/2003
14	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023 - 12/2005
13	MicroRNAs (MicroRNA)IBA 11/2020 - 12/2011
12	secretin receptorIBA 01/2023 - 04/2010
10	MelatoninIBA 01/2022 - 10/2011
8	Proteins (Proteins, Gene)FDA Link 11/2020 - 05/2007
6	Hormones (Hormone)IBA 04/2024 - 07/2007
6	CollagenIBA 12/2023 - 12/2005
6	EnzymesIBA 01/2023 - 05/2012
6	Messenger RNA (mRNA)IBA 01/2023 - 05/2006
6	Bicarbonates (Hydrogen Carbonate)IBA 01/2023 - 11/2004
6	LipidsIBA 10/2021 - 04/2007
6	MorpholinosIBA 11/2020 - 07/2017
6	Histamine Receptors (Histamine Receptor)IBA 01/2018 - 10/2009
5	Phosphotransferases (Kinase)IBA 01/2021 - 07/2013
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2018
5	Histidine DecarboxylaseIBA 10/2016 - 05/2012
4	Chloride-Bicarbonate AntiportersIBA 01/2023 - 04/2010
4	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 06/2002
4	CytokinesIBA 01/2021 - 07/2003
4	FructoseIBA 01/2021 - 01/2018
4	Substance PIBA 11/2020 - 08/2011
4	Vascular Endothelial Growth Factor CIBA 01/2020 - 12/2005
4	Proliferating Cell Nuclear Antigen (PCNA)IBA 05/2014 - 07/2010
3	Estrogens (Estrogen)FDA Link 10/2023 - 10/2004
3	Ethanol (Ethyl Alcohol)IBA 01/2023 - 02/2014
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 04/2020
3	CholesterolIBA 01/2023 - 01/2018
3	Taurocholic Acid (Sodium Taurocholate)IBA 01/2023 - 05/2007
3	DesminIBA 01/2023 - 01/2020
3	Therapeutic UsesIBA 01/2023 - 10/2017
3	Fast GreenIBA 01/2021 - 10/2016
3	Protein Kinases (Protein Kinase)IBA 01/2021 - 10/2009
3	Neurokinin-1 Receptors (Neurokinin 1 Receptor)IBA 11/2020 - 08/2011
3	Carboxy-LyasesIBA 01/2020 - 01/2018
3	Histidine (L-Histidine)FDA Link 01/2020 - 01/2018
3	Arylalkylamine N-AcetyltransferaseIBA 01/2019 - 11/2014
3	Adenosine (Adenocard)FDA LinkGeneric 01/2018 - 05/2007
3	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 11/2016 - 01/2016
3	EndocannabinoidsIBA 12/2008 - 04/2007
2	Estrogen ReceptorsIBA 10/2023 - 09/2006
2	Peptides (Polypeptides)IBA 01/2023 - 04/2015
2	SodiumIBA 01/2023 - 11/2016
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 01/2023 - 12/2005
2	SugarsIBA 01/2023 - 01/2018
2	Cholinergic Agents (Cholinergics)IBA 01/2022 - 10/2007
2	indoleIBA 01/2022 - 10/2020
2	Adenosine Monophosphate (AMP)IBA 01/2022 - 07/2013
2	Choline (Choline Chloride)IBA 01/2022 - 10/2021
2	Melatonin Receptors (Melatonin Receptor)IBA 01/2022 - 10/2011
2	Methionine (L-Methionine)FDA Link 01/2022 - 10/2021
2	Biomarkers (Surrogate Marker)IBA 07/2021 - 01/2021
2	SynaptophysinIBA 01/2021 - 10/2016
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2021 - 10/2016
2	Cyclic AMP (AMP, Cyclic)IBA 01/2021 - 12/2005
2	Insulin (Novolin)FDA Link 01/2021 - 01/2019
2	Small Interfering RNA (siRNA)IBA 11/2020 - 10/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 04/2020
2	VimentinIBA 01/2020 - 10/2019
2	Serotonin (5 Hydroxytryptamine)IBA 01/2020 - 01/2005
2	LipopolysaccharidesIBA 01/2020 - 12/2018
2	Monoamine Oxidase (MAO)IBA 01/2020 - 05/2012
2	Stem Cell FactorIBA 12/2019 - 01/2016
2	Histamine Antagonists (Antihistamines)IBA 01/2019 - 06/2010
2	ATP-Binding Cassette Sub-Family B Member 4IBA 01/2019 - 01/2017
2	NF-kappa B (NF-kB)IBA 01/2019 - 08/2009

Therapy/Procedure

16	Ligation 01/2019 - 10/2004
15	Therapeutics 04/2024 - 06/2007
3	Liver Transplantation 11/2022 - 08/2010
3	Denervation 01/2022 - 05/2007
2	Immunotherapy 01/2022 - 01/2020
2	Drug Therapy (Chemotherapy) 07/2021 - 09/2013